Platelets at the vascular interface

ESSENTIALS: Part 1 of this review summarizes recent findings on the exquisite balance between activating and inhibitory mechanisms that control platelet adhesiveness in the circulation and at sites of vascular injury. Part 2 of this review discusses molecular differences and similarities for how platelets secure vascular integrity at sites of inflammation and at sites of mechanical trauma. In this brief review paper, we will summarize the State‐of‐the‐Art on how platelet reactivity is regulated in circulation and at sites of vascular injury. Our review discusses recent and ongoing work presented at this year's International Society on Thrombosis and Haemostasis (ISTH) meeting, on the role of platelets in (i) classical hemostasis at sites of mechanical injury, and (ii) the maintenance of vascular integrity at sites of inflammation.