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Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood

BACKGROUND: Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prena...

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Autores principales: Gunnarsdottir, Johanna, Cnattingius, Sven, Lundgren, Maria, Selling, Katarina, Högberg, Ulf, Wikström, Anna-Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811001/
https://www.ncbi.nlm.nih.gov/pubmed/29438394
http://dx.doi.org/10.1371/journal.pone.0192514
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author Gunnarsdottir, Johanna
Cnattingius, Sven
Lundgren, Maria
Selling, Katarina
Högberg, Ulf
Wikström, Anna-Karin
author_facet Gunnarsdottir, Johanna
Cnattingius, Sven
Lundgren, Maria
Selling, Katarina
Högberg, Ulf
Wikström, Anna-Karin
author_sort Gunnarsdottir, Johanna
collection PubMed
description BACKGROUND: Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prenatal exposure to preeclampsia is associated with accelerated childhood height gain, also after adjustments for SGA-status and gestational age at birth. METHODS: In a cohort of children prenatally exposed to preeclampsia (n = 865) or unexposed (n = 22,898) we estimated height gain between birth and five years of age. The mean difference in height gain between exposed and unexposed children was calculated and adjustments were done with linear regression models. RESULTS: Children exposed to preeclampsia were on average born shorter than unexposed. Exposed children grew on average two cm more than unexposed from birth to five years of age. After adjustments for maternal characteristics including socioeconomic factors, height, body mass index (BMI) and diabetes, as well as for parents smoking habits, infant’s breastfeeding and childhood obesity, the difference was 1.6 cm (95% CI 1.3–1.9 cm). Further adjustment for SGA birth only slightly attenuated this estimate, but adjustment for gestational age at birth decreased the estimate to 0.5 cm (95% CI 0.1–0.7 cm). CONCLUSION: Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood. The association seemed independent on SGA-status, but partly related to shorter gestational age at birth.
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spelling pubmed-58110012018-02-28 Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood Gunnarsdottir, Johanna Cnattingius, Sven Lundgren, Maria Selling, Katarina Högberg, Ulf Wikström, Anna-Karin PLoS One Research Article BACKGROUND: Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prenatal exposure to preeclampsia is associated with accelerated childhood height gain, also after adjustments for SGA-status and gestational age at birth. METHODS: In a cohort of children prenatally exposed to preeclampsia (n = 865) or unexposed (n = 22,898) we estimated height gain between birth and five years of age. The mean difference in height gain between exposed and unexposed children was calculated and adjustments were done with linear regression models. RESULTS: Children exposed to preeclampsia were on average born shorter than unexposed. Exposed children grew on average two cm more than unexposed from birth to five years of age. After adjustments for maternal characteristics including socioeconomic factors, height, body mass index (BMI) and diabetes, as well as for parents smoking habits, infant’s breastfeeding and childhood obesity, the difference was 1.6 cm (95% CI 1.3–1.9 cm). Further adjustment for SGA birth only slightly attenuated this estimate, but adjustment for gestational age at birth decreased the estimate to 0.5 cm (95% CI 0.1–0.7 cm). CONCLUSION: Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood. The association seemed independent on SGA-status, but partly related to shorter gestational age at birth. Public Library of Science 2018-02-13 /pmc/articles/PMC5811001/ /pubmed/29438394 http://dx.doi.org/10.1371/journal.pone.0192514 Text en © 2018 Gunnarsdottir et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gunnarsdottir, Johanna
Cnattingius, Sven
Lundgren, Maria
Selling, Katarina
Högberg, Ulf
Wikström, Anna-Karin
Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
title Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
title_full Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
title_fullStr Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
title_full_unstemmed Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
title_short Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
title_sort prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811001/
https://www.ncbi.nlm.nih.gov/pubmed/29438394
http://dx.doi.org/10.1371/journal.pone.0192514
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