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Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood
BACKGROUND: Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prena...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811001/ https://www.ncbi.nlm.nih.gov/pubmed/29438394 http://dx.doi.org/10.1371/journal.pone.0192514 |
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author | Gunnarsdottir, Johanna Cnattingius, Sven Lundgren, Maria Selling, Katarina Högberg, Ulf Wikström, Anna-Karin |
author_facet | Gunnarsdottir, Johanna Cnattingius, Sven Lundgren, Maria Selling, Katarina Högberg, Ulf Wikström, Anna-Karin |
author_sort | Gunnarsdottir, Johanna |
collection | PubMed |
description | BACKGROUND: Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prenatal exposure to preeclampsia is associated with accelerated childhood height gain, also after adjustments for SGA-status and gestational age at birth. METHODS: In a cohort of children prenatally exposed to preeclampsia (n = 865) or unexposed (n = 22,898) we estimated height gain between birth and five years of age. The mean difference in height gain between exposed and unexposed children was calculated and adjustments were done with linear regression models. RESULTS: Children exposed to preeclampsia were on average born shorter than unexposed. Exposed children grew on average two cm more than unexposed from birth to five years of age. After adjustments for maternal characteristics including socioeconomic factors, height, body mass index (BMI) and diabetes, as well as for parents smoking habits, infant’s breastfeeding and childhood obesity, the difference was 1.6 cm (95% CI 1.3–1.9 cm). Further adjustment for SGA birth only slightly attenuated this estimate, but adjustment for gestational age at birth decreased the estimate to 0.5 cm (95% CI 0.1–0.7 cm). CONCLUSION: Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood. The association seemed independent on SGA-status, but partly related to shorter gestational age at birth. |
format | Online Article Text |
id | pubmed-5811001 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58110012018-02-28 Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood Gunnarsdottir, Johanna Cnattingius, Sven Lundgren, Maria Selling, Katarina Högberg, Ulf Wikström, Anna-Karin PLoS One Research Article BACKGROUND: Preeclampsia is associated with low birth weight, both because of increased risks of preterm and of small-for-gestational-age (SGA) births. Low birth weight is associated with accelerated childhood height gain and cardiovascular diseases later in life. The aim was to investigate if prenatal exposure to preeclampsia is associated with accelerated childhood height gain, also after adjustments for SGA-status and gestational age at birth. METHODS: In a cohort of children prenatally exposed to preeclampsia (n = 865) or unexposed (n = 22,898) we estimated height gain between birth and five years of age. The mean difference in height gain between exposed and unexposed children was calculated and adjustments were done with linear regression models. RESULTS: Children exposed to preeclampsia were on average born shorter than unexposed. Exposed children grew on average two cm more than unexposed from birth to five years of age. After adjustments for maternal characteristics including socioeconomic factors, height, body mass index (BMI) and diabetes, as well as for parents smoking habits, infant’s breastfeeding and childhood obesity, the difference was 1.6 cm (95% CI 1.3–1.9 cm). Further adjustment for SGA birth only slightly attenuated this estimate, but adjustment for gestational age at birth decreased the estimate to 0.5 cm (95% CI 0.1–0.7 cm). CONCLUSION: Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood. The association seemed independent on SGA-status, but partly related to shorter gestational age at birth. Public Library of Science 2018-02-13 /pmc/articles/PMC5811001/ /pubmed/29438394 http://dx.doi.org/10.1371/journal.pone.0192514 Text en © 2018 Gunnarsdottir et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gunnarsdottir, Johanna Cnattingius, Sven Lundgren, Maria Selling, Katarina Högberg, Ulf Wikström, Anna-Karin Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
title | Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
title_full | Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
title_fullStr | Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
title_full_unstemmed | Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
title_short | Prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
title_sort | prenatal exposure to preeclampsia is associated with accelerated height gain in early childhood |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811001/ https://www.ncbi.nlm.nih.gov/pubmed/29438394 http://dx.doi.org/10.1371/journal.pone.0192514 |
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