Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates expression of low-density lipoprotein (LDL) receptors via receptor internalization and subsequent lysosomal degradation. Thus, an anti-PCSK9 antibody is well known as an anti-hyperlipidemia drug. Here, we aimed to develop vaccine for a...

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Detalles Bibliográficos
Autores principales: Kawakami, Ryo, Nozato, Yoichi, Nakagami, Hironori, Ikeda, Yuka, Shimamura, Munehisa, Yoshida, Shota, Sun, Jiao, Kawano, Tomohiro, Takami, Yoichi, Noma, Takahisa, Rakugi, Hiromi, Minamino, Tetsuo, Morishita, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811007/
https://www.ncbi.nlm.nih.gov/pubmed/29438441
http://dx.doi.org/10.1371/journal.pone.0191895

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