A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition

Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft, a key step in neurotransmission, which is targeted in the treatment of neurological disorders. Cholesterol (CHOL), a major component of the synaptic plasma membrane, has been shown to exhibit a modulatory effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeppelin, Talia, Ladefoged, Lucy Kate, Sinning, Steffen, Periole, Xavier, Schiøtt, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811071/
https://www.ncbi.nlm.nih.gov/pubmed/29329285
http://dx.doi.org/10.1371/journal.pcbi.1005907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811071/
https://www.ncbi.nlm.nih.gov/pubmed/29329285
http://dx.doi.org/10.1371/journal.pcbi.1005907

Ejemplares similares