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Bioorthogonal prodrug activation driven by a strain-promoted 1,3-dipolar cycloaddition

Due to the formation of hydrolysis-susceptible adducts, the 1,3-dipolar cycloaddition between an azide and strained trans-cyclooctene (TCO) has been disregarded in the field of bioorthogonal chemistry. We report a method which uses the instability of the adducts to our advantage in a prodrug activat...

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Detalles Bibliográficos
Autores principales:	Matikonda, Siddharth S., Orsi, Douglas L., Staudacher, Verena, Jenkins, Imogen A., Fiedler, Franziska, Chen, Jiayi, Gamble, Allan B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811098/ https://www.ncbi.nlm.nih.gov/pubmed/29560207 http://dx.doi.org/10.1039/c4sc02574a

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