Mitochondrial genome variability: the effect on cellular functional activity

Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review, we discuss the available information on t...

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Autores principales: Volobueva, Aleksandrina S, Melnichenko, Alexandra A, Grechko, Andrey V, Orekhov, Alexander N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811183/
https://www.ncbi.nlm.nih.gov/pubmed/29467576
http://dx.doi.org/10.2147/TCRM.S153895
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author Volobueva, Aleksandrina S
Melnichenko, Alexandra A
Grechko, Andrey V
Orekhov, Alexander N
author_facet Volobueva, Aleksandrina S
Melnichenko, Alexandra A
Grechko, Andrey V
Orekhov, Alexander N
author_sort Volobueva, Aleksandrina S
collection PubMed
description Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review, we discuss the available information on the involvement of mitochondrial DNA (mtDNA) mutations in cell dysfunction.
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spelling pubmed-58111832018-02-21 Mitochondrial genome variability: the effect on cellular functional activity Volobueva, Aleksandrina S Melnichenko, Alexandra A Grechko, Andrey V Orekhov, Alexander N Ther Clin Risk Manag Review Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review, we discuss the available information on the involvement of mitochondrial DNA (mtDNA) mutations in cell dysfunction. Dove Medical Press 2018-02-09 /pmc/articles/PMC5811183/ /pubmed/29467576 http://dx.doi.org/10.2147/TCRM.S153895 Text en © 2018 Volobueva et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Volobueva, Aleksandrina S
Melnichenko, Alexandra A
Grechko, Andrey V
Orekhov, Alexander N
Mitochondrial genome variability: the effect on cellular functional activity
title Mitochondrial genome variability: the effect on cellular functional activity
title_full Mitochondrial genome variability: the effect on cellular functional activity
title_fullStr Mitochondrial genome variability: the effect on cellular functional activity
title_full_unstemmed Mitochondrial genome variability: the effect on cellular functional activity
title_short Mitochondrial genome variability: the effect on cellular functional activity
title_sort mitochondrial genome variability: the effect on cellular functional activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811183/
https://www.ncbi.nlm.nih.gov/pubmed/29467576
http://dx.doi.org/10.2147/TCRM.S153895
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