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AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

AMP-activated protein kinase (AMPK) is a known regulator of whole-body energy homeostasis, but the downstream AMPK substrates mediating these effects are not entirely clear. AMPK inhibits fatty acid synthesis and promotes fatty acid oxidation by phosphorylation of acetyl-CoA carboxylase (ACC) 1 at S...

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Detalles Bibliográficos
Autores principales:	Galic, Sandra, Loh, Kim, Murray-Segal, Lisa, Steinberg, Gregory R, Andrews, Zane B, Kemp, Bruce E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811211/ https://www.ncbi.nlm.nih.gov/pubmed/29433631 http://dx.doi.org/10.7554/eLife.32656

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