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Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope?
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotectiv...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811233/ https://www.ncbi.nlm.nih.gov/pubmed/29200030 http://dx.doi.org/10.1097/MCO.0000000000000444 |
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author | Beijers, Rosanne J.H.C.G. Gosker, Harry R. Schols, Annemie M.W.J. |
author_facet | Beijers, Rosanne J.H.C.G. Gosker, Harry R. Schols, Annemie M.W.J. |
author_sort | Beijers, Rosanne J.H.C.G. |
collection | PubMed |
description | PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotective potential. Therefore, resveratrol might improve the pulmonary as well as extrapulmonary pathology in COPD. In this review, we will evaluate knowledge on the effects of resveratrol on lung injury, muscle metabolism and cardiovascular risk profile and discuss if resveratrol is a hype or hope for patients with COPD. RECENT FINDINGS: Experimental models of COPD consistently show decreased inflammation and oxidative stress in the lungs after resveratrol treatment. These beneficial anti-inflammatory and antioxidant properties of resveratrol can indirectly also improve both skeletal and respiratory muscle impairment in COPD. Recent clinical studies in non-COPD populations show improved mitochondrial oxidative metabolism after resveratrol treatment, which could be beneficial for both lung and muscle impairment in COPD. Moreover, preclinical studies suggest cardioprotective effects of resveratrol but results of clinical studies are inconclusive. SUMMARY: Resveratrol might be an interesting therapeutic candidate to counteract lung and muscle impairments characteristic to COPD. However, there is no convincing evidence that resveratrol will significantly decrease the cardiovascular risk in patients with COPD. |
format | Online Article Text |
id | pubmed-5811233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-58112332018-03-01 Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? Beijers, Rosanne J.H.C.G. Gosker, Harry R. Schols, Annemie M.W.J. Curr Opin Clin Nutr Metab Care Hot Topics PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with a high prevalence of extrapulmonary manifestations and, frequently, cardiovascular comorbidity. Resveratrol is a food-derived compound with anti-inflammatory, antioxidant, metabolic and cardioprotective potential. Therefore, resveratrol might improve the pulmonary as well as extrapulmonary pathology in COPD. In this review, we will evaluate knowledge on the effects of resveratrol on lung injury, muscle metabolism and cardiovascular risk profile and discuss if resveratrol is a hype or hope for patients with COPD. RECENT FINDINGS: Experimental models of COPD consistently show decreased inflammation and oxidative stress in the lungs after resveratrol treatment. These beneficial anti-inflammatory and antioxidant properties of resveratrol can indirectly also improve both skeletal and respiratory muscle impairment in COPD. Recent clinical studies in non-COPD populations show improved mitochondrial oxidative metabolism after resveratrol treatment, which could be beneficial for both lung and muscle impairment in COPD. Moreover, preclinical studies suggest cardioprotective effects of resveratrol but results of clinical studies are inconclusive. SUMMARY: Resveratrol might be an interesting therapeutic candidate to counteract lung and muscle impairments characteristic to COPD. However, there is no convincing evidence that resveratrol will significantly decrease the cardiovascular risk in patients with COPD. Lippincott Williams & Wilkins 2018-03 2018-02-01 /pmc/articles/PMC5811233/ /pubmed/29200030 http://dx.doi.org/10.1097/MCO.0000000000000444 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Hot Topics Beijers, Rosanne J.H.C.G. Gosker, Harry R. Schols, Annemie M.W.J. Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
title | Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
title_full | Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
title_fullStr | Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
title_full_unstemmed | Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
title_short | Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
title_sort | resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? |
topic | Hot Topics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811233/ https://www.ncbi.nlm.nih.gov/pubmed/29200030 http://dx.doi.org/10.1097/MCO.0000000000000444 |
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