Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model

BACKGROUND: Inducible costimulator (ICOS) is rapidly upregulated with T-cell stimulation and may represent an escape pathway for T-cell costimulation in the setting of CD40/CD154 costimulation blockade. Induction treatment exhibited no efficacy in a primate renal allograft model, but rodent transpla...

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Detalles Bibliográficos
Autores principales: O’Neill, Natalie A., Zhang, Tianshu, Braileanu, Gheorghe, Cheng, Xiangfei, Hershfeld, Alena, Sun, Wenji, Reimann, Keith A., Dahi, Sia, Kubicki, Natalia, Hassanein, Wessam, Laird, Christopher, Cimeno, Arielle, Azimzadeh, Agnes M., Pierson, Richard N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811273/
https://www.ncbi.nlm.nih.gov/pubmed/29464205
http://dx.doi.org/10.1097/TXD.0000000000000761

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