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Two Phase 1, Open‐Label, Mass Balance Studies to Determine the Pharmacokinetics of (14)C‐Labeled Isavuconazonium Sulfate in Healthy Male Volunteers

Isavuconazonium sulfate is the water‐soluble prodrug of the active triazole isavuconazole. Two phase 1 studies were conducted to identify the metabolic profile and mass balance of isavuconazole and BAL8728 (inactive cleavage product). Seven subjects in study 1 (isavuconazole mass balance) received a...

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Detalles Bibliográficos
Autores principales:	Townsend, Robert, Kato, Kota, Hale, Christine, Kowalski, Donna, Lademacher, Christopher, Yamazaki, Takao, Akhtar, Shahzad, Desai, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811773/ https://www.ncbi.nlm.nih.gov/pubmed/28750160 http://dx.doi.org/10.1002/cpdd.376

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