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Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodegeneration remain poorly defined. Given the increasing evidenc...

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Detalles Bibliográficos
Autores principales:	Jeong, Ga Ram, Jang, Eun-Hae, Bae, Jae Ryul, Jun, Soyoung, Kang, Ho Chul, Park, Chi-Hu, Shin, Joo-Ho, Yamamoto, Yukio, Tanaka-Yamamoto, Keiko, Dawson, Valina L., Dawson, Ted M., Hur, Eun-Mi, Lee, Byoung Dae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811984/ https://www.ncbi.nlm.nih.gov/pubmed/29439717 http://dx.doi.org/10.1186/s13024-018-0240-1

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