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Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review
OBJECTIVE: To provide a review of osteochondral lesions of the talus, to discuss the evidence of the risks and benefits of platelet-rich plasma (PRP) as a viable treatment option, and to measure the efficacy of PRP using MRI evidence of cartilage regeneration, as well as scales that measure improvem...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812391/ https://www.ncbi.nlm.nih.gov/pubmed/29464105 http://dx.doi.org/10.1136/bmjsem-2017-000318 |
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author | Elghawy, Ahmed Aly Sesin, Carlos Rosselli, Michael |
author_facet | Elghawy, Ahmed Aly Sesin, Carlos Rosselli, Michael |
author_sort | Elghawy, Ahmed Aly |
collection | PubMed |
description | OBJECTIVE: To provide a review of osteochondral lesions of the talus, to discuss the evidence of the risks and benefits of platelet-rich plasma (PRP) as a viable treatment option, and to measure the efficacy of PRP using MRI evidence of cartilage regeneration, as well as scales that measure improvement in ‘pain’ and ‘functionality’. ELIGIBILITY CRITERIA: Studies that use PRP in either conservative or intraoperative settings to treat osteochondral defects of the talus. RESULTS: There are seven studies that compare hyaluronic acid or standard surgical options against PRP in treating osteochondral lesions of the talus. Five studies use PRP as supplemental treatment in intraoperative settings, while two studies use PRP conservatively as intra-articular injections. There were minimal adverse effects. Pain and functionality scores consistently improved in those who underwent PRP treatments over the course of 4 years. MRI showed significant but inconsistent results in chondral regeneration. CONCLUSION: PRP may show clinical benefit in those with osteochondral lesions of the talus in terms of pain and functionality, although chondral regeneration via MRI is inconsistent. Limitations include the small sample sizes in these seven studies, as well as no standardised formula for PRP preparation. CLINICAL RELEVANCE: To serve as an overview of the literature regarding PRP treatment for osteochondral lesions of the talus and how this modality may improve patient outcomes in pain, functionality and chondral regeneration. A case is reported to complement the subject review. |
format | Online Article Text |
id | pubmed-5812391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-58123912018-02-20 Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review Elghawy, Ahmed Aly Sesin, Carlos Rosselli, Michael BMJ Open Sport Exerc Med Review OBJECTIVE: To provide a review of osteochondral lesions of the talus, to discuss the evidence of the risks and benefits of platelet-rich plasma (PRP) as a viable treatment option, and to measure the efficacy of PRP using MRI evidence of cartilage regeneration, as well as scales that measure improvement in ‘pain’ and ‘functionality’. ELIGIBILITY CRITERIA: Studies that use PRP in either conservative or intraoperative settings to treat osteochondral defects of the talus. RESULTS: There are seven studies that compare hyaluronic acid or standard surgical options against PRP in treating osteochondral lesions of the talus. Five studies use PRP as supplemental treatment in intraoperative settings, while two studies use PRP conservatively as intra-articular injections. There were minimal adverse effects. Pain and functionality scores consistently improved in those who underwent PRP treatments over the course of 4 years. MRI showed significant but inconsistent results in chondral regeneration. CONCLUSION: PRP may show clinical benefit in those with osteochondral lesions of the talus in terms of pain and functionality, although chondral regeneration via MRI is inconsistent. Limitations include the small sample sizes in these seven studies, as well as no standardised formula for PRP preparation. CLINICAL RELEVANCE: To serve as an overview of the literature regarding PRP treatment for osteochondral lesions of the talus and how this modality may improve patient outcomes in pain, functionality and chondral regeneration. A case is reported to complement the subject review. BMJ Publishing Group 2018-02-01 /pmc/articles/PMC5812391/ /pubmed/29464105 http://dx.doi.org/10.1136/bmjsem-2017-000318 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Review Elghawy, Ahmed Aly Sesin, Carlos Rosselli, Michael Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
title | Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
title_full | Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
title_fullStr | Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
title_full_unstemmed | Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
title_short | Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
title_sort | osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812391/ https://www.ncbi.nlm.nih.gov/pubmed/29464105 http://dx.doi.org/10.1136/bmjsem-2017-000318 |
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