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Genome-scale modeling of yeast: chronology, applications and critical perspectives
Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812505/ https://www.ncbi.nlm.nih.gov/pubmed/28899034 http://dx.doi.org/10.1093/femsyr/fox050 |
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author | Lopes, Helder Rocha, Isabel |
author_facet | Lopes, Helder Rocha, Isabel |
author_sort | Lopes, Helder |
collection | PubMed |
description | Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective of the GSMMs built over time for several yeast species is presented and the main inheritance patterns among the metabolic reconstructions are highlighted. We additionally provide a critical perspective on the overall genome-scale modeling procedure, underlining incomplete model validation and evaluation approaches and the quest for the integration of regulatory and kinetic information into yeast GSMMs. A summary of experimentally validated model-based metabolic engineering applications of yeast species is further emphasized, while the main challenges and future perspectives for the field are finally addressed. |
format | Online Article Text |
id | pubmed-5812505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58125052018-02-23 Genome-scale modeling of yeast: chronology, applications and critical perspectives Lopes, Helder Rocha, Isabel FEMS Yeast Res Minireview Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective of the GSMMs built over time for several yeast species is presented and the main inheritance patterns among the metabolic reconstructions are highlighted. We additionally provide a critical perspective on the overall genome-scale modeling procedure, underlining incomplete model validation and evaluation approaches and the quest for the integration of regulatory and kinetic information into yeast GSMMs. A summary of experimentally validated model-based metabolic engineering applications of yeast species is further emphasized, while the main challenges and future perspectives for the field are finally addressed. Oxford University Press 2017-07-10 2017-08 /pmc/articles/PMC5812505/ /pubmed/28899034 http://dx.doi.org/10.1093/femsyr/fox050 Text en © FEMS 2017. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Minireview Lopes, Helder Rocha, Isabel Genome-scale modeling of yeast: chronology, applications and critical perspectives |
title | Genome-scale modeling of yeast: chronology, applications and critical perspectives |
title_full | Genome-scale modeling of yeast: chronology, applications and critical perspectives |
title_fullStr | Genome-scale modeling of yeast: chronology, applications and critical perspectives |
title_full_unstemmed | Genome-scale modeling of yeast: chronology, applications and critical perspectives |
title_short | Genome-scale modeling of yeast: chronology, applications and critical perspectives |
title_sort | genome-scale modeling of yeast: chronology, applications and critical perspectives |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812505/ https://www.ncbi.nlm.nih.gov/pubmed/28899034 http://dx.doi.org/10.1093/femsyr/fox050 |
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