Safety and efficacy of anti-PD-L1 therapy in the woodchuck model of HBV infection

Immune clearance of Hepatitis B virus (HBV) is characterized by broad and robust antiviral T cell responses, while virus-specific T cells in chronic hepatitis B (CHB) are rare and exhibit immune exhaustion that includes programmed-death-1 (PD-1) expression on virus-specific T cells. Thus, an immunot...

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Detalles Bibliográficos
Autores principales: Balsitis, Scott, Gali, Volodymyr, Mason, Pamela J., Chaniewski, Susan, Levine, Steven M., Wichroski, Michael J., Feulner, Michael, Song, Yunling, Granaldi, Karen, Loy, James K., Thompson, Chris M., Lesniak, Jacob A., Brockus, Catherine, Kishnani, Narendra, Menne, Stephan, Cockett, Mark I., Iyer, Renuka, Mason, Stephen W., Tenney, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812555/
https://www.ncbi.nlm.nih.gov/pubmed/29444087
http://dx.doi.org/10.1371/journal.pone.0190058

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