Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

Mutations in the polycystin genes, PKD1 or PKD2, results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we lack a clear understanding of polycystin proteins’ functions as ion channels. This question remains unsolved largely because polycyst...

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Detalles Bibliográficos
Autores principales: Liu, Xiaowen, Vien, Thuy, Duan, Jingjing, Sheu, Shu-Hsien, DeCaen, Paul G, Clapham, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812715/
https://www.ncbi.nlm.nih.gov/pubmed/29443690
http://dx.doi.org/10.7554/eLife.33183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812715/
https://www.ncbi.nlm.nih.gov/pubmed/29443690
http://dx.doi.org/10.7554/eLife.33183

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