Toxicity of PEG-Coated CoFe(2)O(4) Nanoparticles with Treatment Effect of Curcumin

In this work, CoFe(2)O(4) nanoparticles coated with polyethylene glycol (PEG) were successfully synthesized via a hydrothermal technique. Morphological studies of the samples confirmed the formation of polycrystalline pure-phase PEG-CoFe(2)O(4) nanoparticles with sizes of about 24 nm. Toxicity induc...

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Detalles Bibliográficos
Autores principales: Akhtar, Shahnaz, An, Wenzhen, Niu, Xiaoying, Li, Kang, Anwar, Shahzad, Maaz, Khan, Maqbool, Muhammad, Gao, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812961/
https://www.ncbi.nlm.nih.gov/pubmed/29445876
http://dx.doi.org/10.1186/s11671-018-2468-7
Descripción
Sumario:In this work, CoFe(2)O(4) nanoparticles coated with polyethylene glycol (PEG) were successfully synthesized via a hydrothermal technique. Morphological studies of the samples confirmed the formation of polycrystalline pure-phase PEG-CoFe(2)O(4) nanoparticles with sizes of about 24 nm. Toxicity induced by CoFe(2)O(4) nanoparticles was investigated, and biological assays were performed to check the toxicity effects of CoFe(2)O(4) nanoparticles. Moreover, the healing effect of toxicity induced in living organisms was studied using curcumin and it was found that biochemical indexes detoxified and improved to reach its normal level after curcumin administration. Thus, PEG-coated CoFe(2)O(4) synthesized through a hydrothermal method can be utilized in biomedical applications and curcumin, which is a natural chemical with no side effects, can be used for the treatment of toxicity induced by the nanoparticles in living organisms.

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