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Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2

The proto-oncogene c-Myc encodes a short-lived protein c-Myc that regulates various cellular processes including cell growth, differentiation and apoptosis. Degradation of c-Myc is catalyzed by the proteasome and requires phosphorylation of Thr-58 for ubiquitination by E3 ubiquitin ligase, Fbxw7/ FB...

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Detalles Bibliográficos
Autores principales:	Murai, Noriyuki, Murakami, Yasuko, Tajima, Ayasa, Matsufuji, Senya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813005/ https://www.ncbi.nlm.nih.gov/pubmed/29445227 http://dx.doi.org/10.1038/s41598-018-21189-0

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