Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry

T lymphocytes enlarge (blast) and proliferate in response to antigens in a multistep program that involves obligatory cytosolic calcium elevations. Store-operated calcium entry (SOCE) pathway is the primary source of Ca(2+) in these cells. Here, we describe a novel modulator of blastogenesis, prolif...

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Detalles Bibliográficos
Autores principales: Beesetty, Pavani, Wieczerzak, Krystyna B., Gibson, Jennifer N., Kaitsuka, Taku, Luu, Charles Tuan, Matsushita, Masayuki, Kozak, J. Ashot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813043/
https://www.ncbi.nlm.nih.gov/pubmed/29445164
http://dx.doi.org/10.1038/s41598-018-21004-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813043/
https://www.ncbi.nlm.nih.gov/pubmed/29445164
http://dx.doi.org/10.1038/s41598-018-21004-w

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