Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development

With so much emphasis on reducing attrition and becoming more efficient in the delivery of healthcare, there are many opportunities to leverage existing clinical data in drug development and to foster the practice of reverse translation. The application of quantitative approaches to convert clinical...

Descripción completa

Detalles Bibliográficos
Autores principales: Gibbs, John P., Menon, Rajeev, Kasichayanula, Sreeneeranj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813105/
https://www.ncbi.nlm.nih.gov/pubmed/29105747
http://dx.doi.org/10.1002/cpt.897
_version_ 1783300124381806592
author Gibbs, John P.
Menon, Rajeev
Kasichayanula, Sreeneeranj
author_facet Gibbs, John P.
Menon, Rajeev
Kasichayanula, Sreeneeranj
author_sort Gibbs, John P.
collection PubMed
description With so much emphasis on reducing attrition and becoming more efficient in the delivery of healthcare, there are many opportunities to leverage existing clinical data in drug development and to foster the practice of reverse translation. The application of quantitative approaches to convert clinical trial and real‐world data to knowledge will continue to drive innovation. Herein we discuss recent examples of reverse translation and consider future opportunities to capture critical clinical knowledge to inform decision‐making in drug development.
format Online
Article
Text
id pubmed-5813105
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-58131052018-02-16 Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development Gibbs, John P. Menon, Rajeev Kasichayanula, Sreeneeranj Clin Pharmacol Ther Development With so much emphasis on reducing attrition and becoming more efficient in the delivery of healthcare, there are many opportunities to leverage existing clinical data in drug development and to foster the practice of reverse translation. The application of quantitative approaches to convert clinical trial and real‐world data to knowledge will continue to drive innovation. Herein we discuss recent examples of reverse translation and consider future opportunities to capture critical clinical knowledge to inform decision‐making in drug development. John Wiley and Sons Inc. 2017-11-06 2018-02 /pmc/articles/PMC5813105/ /pubmed/29105747 http://dx.doi.org/10.1002/cpt.897 Text en © 2017 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Development
Gibbs, John P.
Menon, Rajeev
Kasichayanula, Sreeneeranj
Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development
title Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development
title_full Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development
title_fullStr Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development
title_full_unstemmed Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development
title_short Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development
title_sort bedside to bench: integrating quantitative clinical pharmacology and reverse translation to optimize drug development
topic Development
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813105/
https://www.ncbi.nlm.nih.gov/pubmed/29105747
http://dx.doi.org/10.1002/cpt.897
work_keys_str_mv AT gibbsjohnp bedsidetobenchintegratingquantitativeclinicalpharmacologyandreversetranslationtooptimizedrugdevelopment
AT menonrajeev bedsidetobenchintegratingquantitativeclinicalpharmacologyandreversetranslationtooptimizedrugdevelopment
AT kasichayanulasreeneeranj bedsidetobenchintegratingquantitativeclinicalpharmacologyandreversetranslationtooptimizedrugdevelopment

Ejemplares similares