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Enhanced Permeability and Binding Activity of Isobutylene‐Grafted Peptides

We present a new peptide‐macrocyclization strategy with an isobutylene graft. The reaction is mild and proceeds rapidly and efficiently both for linear and cyclic peptides. The resulting isobutylene‐grafted peptides possess improved passive membrane permeability due to the shielding of the polar bac...

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Detalles Bibliográficos
Autores principales:	Sun, Shuang, Compañón, Ismael, Martínez‐Sáez, Nuria, Seixas, João D., Boutureira, Omar, Corzana, Francisco, Bernardes, Gonçalo J. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813187/ https://www.ncbi.nlm.nih.gov/pubmed/29105291 http://dx.doi.org/10.1002/cbic.201700586

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