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Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes

BACKGROUND: People with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one potential cause of this exercise defect. Acute infusion of vitamin C has been separa...

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Autores principales: Scalzo, Rebecca L., Bauer, Timothy A., Harrall, Kylie, Moreau, Kerrie, Ozemek, Cemal, Herlache, Leah, McMillin, Shawna, Huebschmann, Amy G., Dorosz, Jennifer, Reusch, Jane E. B., Regensteiner, Judith G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813393/
https://www.ncbi.nlm.nih.gov/pubmed/29456629
http://dx.doi.org/10.1186/s13098-018-0306-9
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author Scalzo, Rebecca L.
Bauer, Timothy A.
Harrall, Kylie
Moreau, Kerrie
Ozemek, Cemal
Herlache, Leah
McMillin, Shawna
Huebschmann, Amy G.
Dorosz, Jennifer
Reusch, Jane E. B.
Regensteiner, Judith G.
author_facet Scalzo, Rebecca L.
Bauer, Timothy A.
Harrall, Kylie
Moreau, Kerrie
Ozemek, Cemal
Herlache, Leah
McMillin, Shawna
Huebschmann, Amy G.
Dorosz, Jennifer
Reusch, Jane E. B.
Regensteiner, Judith G.
author_sort Scalzo, Rebecca L.
collection PubMed
description BACKGROUND: People with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one potential cause of this exercise defect. Acute infusion of vitamin C has been separately shown to improve diastolic and endothelial function in prior studies. We hypothesized that acute vitamin C infusion would improve exercise capacity and that these improvements would be associated with improved cardiovascular function. METHODS: Adults with T2D (n = 31, 7 female, 24 male, body mass index (BMI): 31.5 ± 0.8 kg/m(2)) and BMI-similar healthy adults (n = 21, 11 female, 10 male, BMI: 30.4 ± 0.7 kg/m(2)) completed two randomly ordered visits: IV infusion of vitamin C (7.5 g) and a volume-matched saline infusion. During each visit peak oxygen uptake (VO(2)peak), brachial artery flow mediated dilation (FMD), reactive hyperemia (RH; plethysmography), and cardiac echocardiography were measured. General linear mixed models were utilized to assess the differences in all study variables. RESULTS: Acute vitamin C infusion improved diastolic function, assessed by lateral and septal E:E’ (P < 0.01), but did not change RH (P = 0.92), or VO(2)peak (P = 0.33) in any participants. CONCLUSION: Acute vitamin C infusion improved diastolic function but did not change FMD, forearm reactive hyperemia, or peak exercise capacity. Future studies should further clarify the role of endothelial function as well as other possible physiological causes of exercise impairment in order to provide potential therapeutic targets. Trial registration NCT00786019. Prospectively registered May 2008
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spelling pubmed-58133932018-02-16 Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes Scalzo, Rebecca L. Bauer, Timothy A. Harrall, Kylie Moreau, Kerrie Ozemek, Cemal Herlache, Leah McMillin, Shawna Huebschmann, Amy G. Dorosz, Jennifer Reusch, Jane E. B. Regensteiner, Judith G. Diabetol Metab Syndr Research BACKGROUND: People with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one potential cause of this exercise defect. Acute infusion of vitamin C has been separately shown to improve diastolic and endothelial function in prior studies. We hypothesized that acute vitamin C infusion would improve exercise capacity and that these improvements would be associated with improved cardiovascular function. METHODS: Adults with T2D (n = 31, 7 female, 24 male, body mass index (BMI): 31.5 ± 0.8 kg/m(2)) and BMI-similar healthy adults (n = 21, 11 female, 10 male, BMI: 30.4 ± 0.7 kg/m(2)) completed two randomly ordered visits: IV infusion of vitamin C (7.5 g) and a volume-matched saline infusion. During each visit peak oxygen uptake (VO(2)peak), brachial artery flow mediated dilation (FMD), reactive hyperemia (RH; plethysmography), and cardiac echocardiography were measured. General linear mixed models were utilized to assess the differences in all study variables. RESULTS: Acute vitamin C infusion improved diastolic function, assessed by lateral and septal E:E’ (P < 0.01), but did not change RH (P = 0.92), or VO(2)peak (P = 0.33) in any participants. CONCLUSION: Acute vitamin C infusion improved diastolic function but did not change FMD, forearm reactive hyperemia, or peak exercise capacity. Future studies should further clarify the role of endothelial function as well as other possible physiological causes of exercise impairment in order to provide potential therapeutic targets. Trial registration NCT00786019. Prospectively registered May 2008 BioMed Central 2018-02-14 /pmc/articles/PMC5813393/ /pubmed/29456629 http://dx.doi.org/10.1186/s13098-018-0306-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Scalzo, Rebecca L.
Bauer, Timothy A.
Harrall, Kylie
Moreau, Kerrie
Ozemek, Cemal
Herlache, Leah
McMillin, Shawna
Huebschmann, Amy G.
Dorosz, Jennifer
Reusch, Jane E. B.
Regensteiner, Judith G.
Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes
title Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes
title_full Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes
title_fullStr Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes
title_full_unstemmed Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes
title_short Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes
title_sort acute vitamin c improves cardiac function, not exercise capacity, in adults with type 2 diabetes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813393/
https://www.ncbi.nlm.nih.gov/pubmed/29456629
http://dx.doi.org/10.1186/s13098-018-0306-9
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