Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report

BACKGROUND: Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration...

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Autores principales: Guo, Wei, Guo, Shao-Chun, Li, Min, Li, Li-Hong, Qu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813425/
https://www.ncbi.nlm.nih.gov/pubmed/29456841
http://dx.doi.org/10.1186/s13756-018-0313-5
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author Guo, Wei
Guo, Shao-Chun
Li, Min
Li, Li-Hong
Qu, Yan
author_facet Guo, Wei
Guo, Shao-Chun
Li, Min
Li, Li-Hong
Qu, Yan
author_sort Guo, Wei
collection PubMed
description BACKGROUND: Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier. CASE PRESENTATION: A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of Acinetobacter baumannii after the decompressive craniectomy for severe traumatic brain injury. The patient was successfully treated with intraventricular and intravenous polymyxin B together with intravenous tigecycline. CONCLUSIONS: The case illustrates intraventricular polymyxin B can be a therapeutic option against extensively drug-resistant Acinetobacter baumannii ventriculitis.
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spelling pubmed-58134252018-02-16 Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report Guo, Wei Guo, Shao-Chun Li, Min Li, Li-Hong Qu, Yan Antimicrob Resist Infect Control Case Report BACKGROUND: Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier. CASE PRESENTATION: A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of Acinetobacter baumannii after the decompressive craniectomy for severe traumatic brain injury. The patient was successfully treated with intraventricular and intravenous polymyxin B together with intravenous tigecycline. CONCLUSIONS: The case illustrates intraventricular polymyxin B can be a therapeutic option against extensively drug-resistant Acinetobacter baumannii ventriculitis. BioMed Central 2018-02-14 /pmc/articles/PMC5813425/ /pubmed/29456841 http://dx.doi.org/10.1186/s13756-018-0313-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Guo, Wei
Guo, Shao-Chun
Li, Min
Li, Li-Hong
Qu, Yan
Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report
title Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report
title_full Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report
title_fullStr Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report
title_full_unstemmed Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report
title_short Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report
title_sort successful treatment of extensively drug-resistant acinetobacter baumannii ventriculitis with polymyxin b and tigecycline- a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813425/
https://www.ncbi.nlm.nih.gov/pubmed/29456841
http://dx.doi.org/10.1186/s13756-018-0313-5
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