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Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation

Introduction: Recently, radiofrequency ablation (RFA) has been increasingly used for the treatment of thyroid nodules. However, immediate morphological changes associated with bipolar devices are poorly shown. Aims: To present the results of analysis of gross and microscopic alterations in human thy...

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Autores principales: Branovan, Daniel Igor, Fridman, Mikhail, Lushchyk, Maxim, Drozd, Valentina, Krasko, Olga, Nedzvedz, Olga, Shiglik, Nikolay, Danilova, Larisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Touch Medical Media 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813447/
https://www.ncbi.nlm.nih.gov/pubmed/29632593
http://dx.doi.org/10.17925/EE.2016.12.02.85
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author Branovan, Daniel Igor
Fridman, Mikhail
Lushchyk, Maxim
Drozd, Valentina
Krasko, Olga
Nedzvedz, Olga
Shiglik, Nikolay
Danilova, Larisa
author_facet Branovan, Daniel Igor
Fridman, Mikhail
Lushchyk, Maxim
Drozd, Valentina
Krasko, Olga
Nedzvedz, Olga
Shiglik, Nikolay
Danilova, Larisa
author_sort Branovan, Daniel Igor
collection PubMed
description Introduction: Recently, radiofrequency ablation (RFA) has been increasingly used for the treatment of thyroid nodules. However, immediate morphological changes associated with bipolar devices are poorly shown. Aims: To present the results of analysis of gross and microscopic alterations in human thyroid tissue induced by RFA delivered through the application of the original patented device. Materials and methods: In total, there were 37 surgically removed thyroid glands in females aged 32–67 at presentation: 16 nodules were follicular adenoma (labelled as ‘parenchymal’ solid benign nodules) and adenomatous colloid goitre was represented by 21 cases. The thyroid gland was routinely processed and the nodules were sliced into two parts – one was a subject for histological routine processing according to the principles that universally apply in surgical pathology, the other one was used for the RFA procedure. Results: No significant difference in size reduction between parenchymal and colloid nodules was revealed (p>0.1, t-test) straight after the treatment. In addition, RFA equally effectively induced necrosis in follicular adenoma and adenomatous colloid goitre (p>0.1, analysis of variance test). As expected, tumour size correlated with size reduction (the smaller the size of the nodule, the greater percentage of the nodule volume that was ablated): r=-0.48 (p<0.0001). Conclusion: The results make it possible to move from ex vivo experiments to clinical practice.
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spelling pubmed-58134472018-04-09 Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation Branovan, Daniel Igor Fridman, Mikhail Lushchyk, Maxim Drozd, Valentina Krasko, Olga Nedzvedz, Olga Shiglik, Nikolay Danilova, Larisa Eur Endocrinol Original Research Thyroid Disorders Introduction: Recently, radiofrequency ablation (RFA) has been increasingly used for the treatment of thyroid nodules. However, immediate morphological changes associated with bipolar devices are poorly shown. Aims: To present the results of analysis of gross and microscopic alterations in human thyroid tissue induced by RFA delivered through the application of the original patented device. Materials and methods: In total, there were 37 surgically removed thyroid glands in females aged 32–67 at presentation: 16 nodules were follicular adenoma (labelled as ‘parenchymal’ solid benign nodules) and adenomatous colloid goitre was represented by 21 cases. The thyroid gland was routinely processed and the nodules were sliced into two parts – one was a subject for histological routine processing according to the principles that universally apply in surgical pathology, the other one was used for the RFA procedure. Results: No significant difference in size reduction between parenchymal and colloid nodules was revealed (p>0.1, t-test) straight after the treatment. In addition, RFA equally effectively induced necrosis in follicular adenoma and adenomatous colloid goitre (p>0.1, analysis of variance test). As expected, tumour size correlated with size reduction (the smaller the size of the nodule, the greater percentage of the nodule volume that was ablated): r=-0.48 (p<0.0001). Conclusion: The results make it possible to move from ex vivo experiments to clinical practice. Touch Medical Media 2016-08 2016-08-28 /pmc/articles/PMC5813447/ /pubmed/29632593 http://dx.doi.org/10.17925/EE.2016.12.02.85 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by/2.5/ This article is published under the Creative Commons Attribution Noncommercial License, which permits any non-commercial use, distribution, adaptation and reproduction provided the original author(s) and source are given appropriate credit.
spellingShingle Original Research Thyroid Disorders
Branovan, Daniel Igor
Fridman, Mikhail
Lushchyk, Maxim
Drozd, Valentina
Krasko, Olga
Nedzvedz, Olga
Shiglik, Nikolay
Danilova, Larisa
Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
title Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
title_full Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
title_fullStr Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
title_full_unstemmed Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
title_short Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules – a Preclinical Ex Vivo Investigation
title_sort morphological changes induced by bipolar radiofrequency ablation in thyroid nodules – a preclinical ex vivo investigation
topic Original Research Thyroid Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813447/
https://www.ncbi.nlm.nih.gov/pubmed/29632593
http://dx.doi.org/10.17925/EE.2016.12.02.85
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