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Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens
Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood. Central T cell tolerance is mediated through presentation of self-antigens by cells constituting...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813500/ https://www.ncbi.nlm.nih.gov/pubmed/29386114 http://dx.doi.org/10.1016/j.celrep.2018.01.015 |