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Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

CD4(+) T cells convert the time that T cell receptors (TCRs) interact with peptides embedded within class II major histocompatibility complex molecules (pMHCII) into signals that direct cell-fate decisions. In principle, TCRs relay information to intracellular signaling motifs of the associated CD3...

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Detalles Bibliográficos
Autores principales:	Glassman, Caleb R., Parrish, Heather L., Lee, Mark S., Kuhns, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813697/ https://www.ncbi.nlm.nih.gov/pubmed/29386113 http://dx.doi.org/10.1016/j.celrep.2017.12.104

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