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Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients
The diverging evidence for functional localization of response inhibition within the prefrontal cortex might be justified by the still unclear involvement of other intrinsically related cognitive processes like response selection and sustained attention. In this study, the main aim was to understand...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pergamon Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813715/ https://www.ncbi.nlm.nih.gov/pubmed/28412512 http://dx.doi.org/10.1016/j.neuropsychologia.2017.04.018 |
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author | Arbula, Sandra Pacella, Valentina De Pellegrin, Serena Rossetto, Marta Denaro, Luca D’Avella, Domenico Della Puppa, Alessandro Vallesi, Antonino |
author_facet | Arbula, Sandra Pacella, Valentina De Pellegrin, Serena Rossetto, Marta Denaro, Luca D’Avella, Domenico Della Puppa, Alessandro Vallesi, Antonino |
author_sort | Arbula, Sandra |
collection | PubMed |
description | The diverging evidence for functional localization of response inhibition within the prefrontal cortex might be justified by the still unclear involvement of other intrinsically related cognitive processes like response selection and sustained attention. In this study, the main aim was to understand whether inhibitory impairments, previously found in patients with both left and right frontal lesions, could be better accounted for by assessing these potentially related cognitive processes. We tested 37 brain tumor patients with left prefrontal, right prefrontal and non-prefrontal lesions and a healthy control group on Go/No-Go and Foreperiod tasks. In both types of tasks inhibitory impairments are likely to cause false alarms, although additionally the former task requires response selection and the latter target detection abilities. Irrespective of the task context, patients with right prefrontal damage showed frequent Go and target omissions, probably due to sustained attention lapses. Left prefrontal patients, on the other hand, showed both Go and target omissions and high false alarm rates to No-Go and warning stimuli, suggesting a decisional rather than an inhibitory impairment. An exploratory whole-brain voxel-based lesion-symptom mapping analysis confirmed the association of left ventrolateral and dorsolateral prefrontal lesions with target discrimination failure, and right ventrolateral and medial prefrontal lesions with target detection failure. Results from this study show how left and right prefrontal areas, which previous research has linked to response inhibition, underlie broader cognitive control processes, particularly involved in response selection and target detection. Based on these findings, we suggest that successful inhibitory control relies on more than one functionally distinct process which, if assessed appropriately, might help us to better understand inhibitory impairments across different pathologies. |
format | Online Article Text |
id | pubmed-5813715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Pergamon Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58137152018-02-20 Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients Arbula, Sandra Pacella, Valentina De Pellegrin, Serena Rossetto, Marta Denaro, Luca D’Avella, Domenico Della Puppa, Alessandro Vallesi, Antonino Neuropsychologia Article The diverging evidence for functional localization of response inhibition within the prefrontal cortex might be justified by the still unclear involvement of other intrinsically related cognitive processes like response selection and sustained attention. In this study, the main aim was to understand whether inhibitory impairments, previously found in patients with both left and right frontal lesions, could be better accounted for by assessing these potentially related cognitive processes. We tested 37 brain tumor patients with left prefrontal, right prefrontal and non-prefrontal lesions and a healthy control group on Go/No-Go and Foreperiod tasks. In both types of tasks inhibitory impairments are likely to cause false alarms, although additionally the former task requires response selection and the latter target detection abilities. Irrespective of the task context, patients with right prefrontal damage showed frequent Go and target omissions, probably due to sustained attention lapses. Left prefrontal patients, on the other hand, showed both Go and target omissions and high false alarm rates to No-Go and warning stimuli, suggesting a decisional rather than an inhibitory impairment. An exploratory whole-brain voxel-based lesion-symptom mapping analysis confirmed the association of left ventrolateral and dorsolateral prefrontal lesions with target discrimination failure, and right ventrolateral and medial prefrontal lesions with target detection failure. Results from this study show how left and right prefrontal areas, which previous research has linked to response inhibition, underlie broader cognitive control processes, particularly involved in response selection and target detection. Based on these findings, we suggest that successful inhibitory control relies on more than one functionally distinct process which, if assessed appropriately, might help us to better understand inhibitory impairments across different pathologies. Pergamon Press 2017-06 /pmc/articles/PMC5813715/ /pubmed/28412512 http://dx.doi.org/10.1016/j.neuropsychologia.2017.04.018 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Arbula, Sandra Pacella, Valentina De Pellegrin, Serena Rossetto, Marta Denaro, Luca D’Avella, Domenico Della Puppa, Alessandro Vallesi, Antonino Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients |
title | Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients |
title_full | Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients |
title_fullStr | Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients |
title_full_unstemmed | Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients |
title_short | Addressing the selective role of distinct prefrontal areas in response suppression: A study with brain tumor patients |
title_sort | addressing the selective role of distinct prefrontal areas in response suppression: a study with brain tumor patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813715/ https://www.ncbi.nlm.nih.gov/pubmed/28412512 http://dx.doi.org/10.1016/j.neuropsychologia.2017.04.018 |
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