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A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells
Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these ther...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813951/ https://www.ncbi.nlm.nih.gov/pubmed/29483778 http://dx.doi.org/10.2147/SCCAA.S135415 |
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author | Shroff, Geeta |
author_facet | Shroff, Geeta |
author_sort | Shroff, Geeta |
collection | PubMed |
description | Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these therapies are associated with major CNS and cardiovascular adverse events, and prolonged use of these treatments may cause life-threatening diseases. Recent research has shown that cellular therapies hold a potential for CNS repair and may be able to provide protection from inflammatory damage caused after injury. Human embryonic stem cell (hESC) transplantation is one of the promising cell therapies; hESCs play an important role in remyelination and help in preventing demylenation of the axons. In this study, an overview of the current knowledge about the unique properties of hESC and their comparison with other cell therapies has been presented for the treatment of patients with MS. |
format | Online Article Text |
id | pubmed-5813951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58139512018-02-26 A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells Shroff, Geeta Stem Cells Cloning Review Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these therapies are associated with major CNS and cardiovascular adverse events, and prolonged use of these treatments may cause life-threatening diseases. Recent research has shown that cellular therapies hold a potential for CNS repair and may be able to provide protection from inflammatory damage caused after injury. Human embryonic stem cell (hESC) transplantation is one of the promising cell therapies; hESCs play an important role in remyelination and help in preventing demylenation of the axons. In this study, an overview of the current knowledge about the unique properties of hESC and their comparison with other cell therapies has been presented for the treatment of patients with MS. Dove Medical Press 2018-02-12 /pmc/articles/PMC5813951/ /pubmed/29483778 http://dx.doi.org/10.2147/SCCAA.S135415 Text en © 2018 Shroff. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Shroff, Geeta A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
title | A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
title_full | A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
title_fullStr | A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
title_full_unstemmed | A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
title_short | A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
title_sort | review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813951/ https://www.ncbi.nlm.nih.gov/pubmed/29483778 http://dx.doi.org/10.2147/SCCAA.S135415 |
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