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Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP)
BACKGROUND: Although viruses are known to be the second most common etiological factor in community-acquired pneumonia (CAP), the respiratory viral profile of the patients with healthcare-associated pneumonia (HCAP) has not yet been elucidated. We investigated the prevalence and the clinical impact...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813982/ https://www.ncbi.nlm.nih.gov/pubmed/29447204 http://dx.doi.org/10.1371/journal.pone.0192893 |
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author | Kim, Eun Sun Park, Kyoung Un Lee, Sang Hoon Lee, Yeon Joo Park, Jong Sun Cho, Young-Jae Yoon, Ho Il Lee, Choon-Taek Lee, Jae Ho |
author_facet | Kim, Eun Sun Park, Kyoung Un Lee, Sang Hoon Lee, Yeon Joo Park, Jong Sun Cho, Young-Jae Yoon, Ho Il Lee, Choon-Taek Lee, Jae Ho |
author_sort | Kim, Eun Sun |
collection | PubMed |
description | BACKGROUND: Although viruses are known to be the second most common etiological factor in community-acquired pneumonia (CAP), the respiratory viral profile of the patients with healthcare-associated pneumonia (HCAP) has not yet been elucidated. We investigated the prevalence and the clinical impact of respiratory virus infection in adult patients with HCAP. METHODS: Patients admitted with HCAP or CAP, between January and December 2016, to a tertiary referral hospital in Korea, were prospectively enrolled, and virus identification was performed using reverse-transcription polymerase chain reaction (RT-PCR). RESULTS: Among 452 enrolled patients (224 with HCAP, 228 with CAP), samples for respiratory viruses were collected from sputum or endotracheal aspirate in 430 (95.1%) patients and from nasopharyngeal specimens in 22 (4.9%) patients. Eighty-seven (19.2%) patients had a viral infection, and the proportion of those with viral infection was significantly lower in the HCAP than in the CAP group (13.8% vs 24.6%, p = 0.004). In both the HCAP and CAP groups, influenza A was the most common respiratory virus, followed by entero-rhinovirus. The seasonal distributions of respiratory viruses were also similar in both groups. In the HCAP group, the viral infection resulted in a similar length of hospital stay and in-hospital mortality as viral–bacterial coinfection and bacterial infection, and the CAP group showed similar results. CONCLUSIONS: The prevalence of viral infection in patients with HCAP was lower than that in patients with CAP, and resulted in a similar prognosis as viral–bacterial coinfection or bacterial infection. |
format | Online Article Text |
id | pubmed-5813982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58139822018-03-02 Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) Kim, Eun Sun Park, Kyoung Un Lee, Sang Hoon Lee, Yeon Joo Park, Jong Sun Cho, Young-Jae Yoon, Ho Il Lee, Choon-Taek Lee, Jae Ho PLoS One Research Article BACKGROUND: Although viruses are known to be the second most common etiological factor in community-acquired pneumonia (CAP), the respiratory viral profile of the patients with healthcare-associated pneumonia (HCAP) has not yet been elucidated. We investigated the prevalence and the clinical impact of respiratory virus infection in adult patients with HCAP. METHODS: Patients admitted with HCAP or CAP, between January and December 2016, to a tertiary referral hospital in Korea, were prospectively enrolled, and virus identification was performed using reverse-transcription polymerase chain reaction (RT-PCR). RESULTS: Among 452 enrolled patients (224 with HCAP, 228 with CAP), samples for respiratory viruses were collected from sputum or endotracheal aspirate in 430 (95.1%) patients and from nasopharyngeal specimens in 22 (4.9%) patients. Eighty-seven (19.2%) patients had a viral infection, and the proportion of those with viral infection was significantly lower in the HCAP than in the CAP group (13.8% vs 24.6%, p = 0.004). In both the HCAP and CAP groups, influenza A was the most common respiratory virus, followed by entero-rhinovirus. The seasonal distributions of respiratory viruses were also similar in both groups. In the HCAP group, the viral infection resulted in a similar length of hospital stay and in-hospital mortality as viral–bacterial coinfection and bacterial infection, and the CAP group showed similar results. CONCLUSIONS: The prevalence of viral infection in patients with HCAP was lower than that in patients with CAP, and resulted in a similar prognosis as viral–bacterial coinfection or bacterial infection. Public Library of Science 2018-02-15 /pmc/articles/PMC5813982/ /pubmed/29447204 http://dx.doi.org/10.1371/journal.pone.0192893 Text en © 2018 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Eun Sun Park, Kyoung Un Lee, Sang Hoon Lee, Yeon Joo Park, Jong Sun Cho, Young-Jae Yoon, Ho Il Lee, Choon-Taek Lee, Jae Ho Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) |
title | Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) |
title_full | Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) |
title_fullStr | Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) |
title_full_unstemmed | Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) |
title_short | Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) |
title_sort | comparison of viral infection in healthcare-associated pneumonia (hcap) and community-acquired pneumonia (cap) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813982/ https://www.ncbi.nlm.nih.gov/pubmed/29447204 http://dx.doi.org/10.1371/journal.pone.0192893 |
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