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Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation

Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn’s disease (CD) patients is correlated with loss of tolerance against the host gut flora. Gp96 has been stablished to be an essential chaperone for Toll-like receptors (TLRs). We st...

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Detalles Bibliográficos
Autores principales:	Cosin-Roger, Jesus, Spalinger, Marianne R., Ruiz, Pedro A., Stanzel, Claudia, Terhalle, Anne, Wolfram, Lutz, Melhem, Hassan, Atrott, Kirstin, Lang, Silvia, Frey-Wagner, Isabelle, Fried, Michael, Scharl, Michael, Hausmann, Martin, Rogler, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814018/ https://www.ncbi.nlm.nih.gov/pubmed/29447283 http://dx.doi.org/10.1371/journal.pone.0193003

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