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Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus

BACKGROUND: The association of alcohol intake with the incidence of Barrett’s esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown. AIM: To investigate whe...

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Autores principales: Masuda, Atsuhiro, Fujita, Tsuyoshi, Murakami, Manabu, Yamazaki, Yukinao, Kobayashi, Masao, Terao, Shuichi, Sanuki, Tsuyoshi, Okada, Akihiko, Adachi, Masayasu, Shiomi, Hideyuki, Arisaka, Yoshifumi, Kutsumi, Hiromu, Umegaki, Eiji, Azuma, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814023/
https://www.ncbi.nlm.nih.gov/pubmed/29447244
http://dx.doi.org/10.1371/journal.pone.0192951
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author Masuda, Atsuhiro
Fujita, Tsuyoshi
Murakami, Manabu
Yamazaki, Yukinao
Kobayashi, Masao
Terao, Shuichi
Sanuki, Tsuyoshi
Okada, Akihiko
Adachi, Masayasu
Shiomi, Hideyuki
Arisaka, Yoshifumi
Kutsumi, Hiromu
Umegaki, Eiji
Azuma, Takeshi
author_facet Masuda, Atsuhiro
Fujita, Tsuyoshi
Murakami, Manabu
Yamazaki, Yukinao
Kobayashi, Masao
Terao, Shuichi
Sanuki, Tsuyoshi
Okada, Akihiko
Adachi, Masayasu
Shiomi, Hideyuki
Arisaka, Yoshifumi
Kutsumi, Hiromu
Umegaki, Eiji
Azuma, Takeshi
author_sort Masuda, Atsuhiro
collection PubMed
description BACKGROUND: The association of alcohol intake with the incidence of Barrett’s esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown. AIM: To investigate whether the influence of alcohol intake on the occurrence of BE might differ depending on male sex and presence of hiatal hernia. METHODS: We utilized a database of 8031 patients that underwent upper endoscopy for health screening in a prospective, multicenter, cohort study (the Upper Gastro Intestinal Disease study). The incidence of endoscopic columnar-lined esophagus (eCLE; endoscopically diagnosed BE) was the outcome variable. Multivariable logistic regression analysis was conducted to assess the association between alcohol intake and eCLE stratified by male sex and hiatal hernia, adjusting for clinical features and other potential confounders. RESULTS: Alcohol intake (≥20 g/day) showed a marginally significant association with the incidence of eCLE in participants without hiatal hernia (0 vs. ≥20 g/day; odds ratio [OR], 1.62; 95% confidence interval [CI], 0.92–2.85, P = 0.09) but not in participants with hiatal hernia (0 vs. ≥20/day; OR, 0.99; 95% CI, 0.59–1.65; P = 0.95). Furthermore, alcohol intake (≥20 g/day) was significantly associated with the incidence of eCLE in male participants without hiatal hernia (0 vs. ≥20 g/day; OR, 1.98; 95% CI, 1.04–4.03; P = 0.04) but not in female participants without hiatal hernia (0 vs. ≥20 g/day; OR, 0.47; 95% CI, 0.03–2.37; P = 0.42). CONCLUSIONS: The effect of alcohol intake on the incidence of eCLE might be associated with hiatal hernia status and male sex.
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spelling pubmed-58140232018-03-02 Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus Masuda, Atsuhiro Fujita, Tsuyoshi Murakami, Manabu Yamazaki, Yukinao Kobayashi, Masao Terao, Shuichi Sanuki, Tsuyoshi Okada, Akihiko Adachi, Masayasu Shiomi, Hideyuki Arisaka, Yoshifumi Kutsumi, Hiromu Umegaki, Eiji Azuma, Takeshi PLoS One Research Article BACKGROUND: The association of alcohol intake with the incidence of Barrett’s esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown. AIM: To investigate whether the influence of alcohol intake on the occurrence of BE might differ depending on male sex and presence of hiatal hernia. METHODS: We utilized a database of 8031 patients that underwent upper endoscopy for health screening in a prospective, multicenter, cohort study (the Upper Gastro Intestinal Disease study). The incidence of endoscopic columnar-lined esophagus (eCLE; endoscopically diagnosed BE) was the outcome variable. Multivariable logistic regression analysis was conducted to assess the association between alcohol intake and eCLE stratified by male sex and hiatal hernia, adjusting for clinical features and other potential confounders. RESULTS: Alcohol intake (≥20 g/day) showed a marginally significant association with the incidence of eCLE in participants without hiatal hernia (0 vs. ≥20 g/day; odds ratio [OR], 1.62; 95% confidence interval [CI], 0.92–2.85, P = 0.09) but not in participants with hiatal hernia (0 vs. ≥20/day; OR, 0.99; 95% CI, 0.59–1.65; P = 0.95). Furthermore, alcohol intake (≥20 g/day) was significantly associated with the incidence of eCLE in male participants without hiatal hernia (0 vs. ≥20 g/day; OR, 1.98; 95% CI, 1.04–4.03; P = 0.04) but not in female participants without hiatal hernia (0 vs. ≥20 g/day; OR, 0.47; 95% CI, 0.03–2.37; P = 0.42). CONCLUSIONS: The effect of alcohol intake on the incidence of eCLE might be associated with hiatal hernia status and male sex. Public Library of Science 2018-02-15 /pmc/articles/PMC5814023/ /pubmed/29447244 http://dx.doi.org/10.1371/journal.pone.0192951 Text en © 2018 Masuda et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Masuda, Atsuhiro
Fujita, Tsuyoshi
Murakami, Manabu
Yamazaki, Yukinao
Kobayashi, Masao
Terao, Shuichi
Sanuki, Tsuyoshi
Okada, Akihiko
Adachi, Masayasu
Shiomi, Hideyuki
Arisaka, Yoshifumi
Kutsumi, Hiromu
Umegaki, Eiji
Azuma, Takeshi
Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus
title Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus
title_full Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus
title_fullStr Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus
title_full_unstemmed Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus
title_short Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett’s esophagus
title_sort influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of barrett’s esophagus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814023/
https://www.ncbi.nlm.nih.gov/pubmed/29447244
http://dx.doi.org/10.1371/journal.pone.0192951
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