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Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display
Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. Pharmacological inhibitors of IDE administered internally have been shown to slow the breakdow...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814047/ https://www.ncbi.nlm.nih.gov/pubmed/29447281 http://dx.doi.org/10.1371/journal.pone.0193101 |