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Relationship between serum bilirubin levels and cardiovascular disease
We tested the hypothesis that higher levels of bilirubin, a bile pigment with antioxidant properties, are associated with a decreased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the association between serum total bilirubin (TB) o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814053/ https://www.ncbi.nlm.nih.gov/pubmed/29447261 http://dx.doi.org/10.1371/journal.pone.0193041 |
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author | Suh, Sunghwan Cho, Young Rak Park, Mi Kyoung Kim, Duk Kyu Cho, Nam H. Lee, Moon-Kyu |
author_facet | Suh, Sunghwan Cho, Young Rak Park, Mi Kyoung Kim, Duk Kyu Cho, Nam H. Lee, Moon-Kyu |
author_sort | Suh, Sunghwan |
collection | PubMed |
description | We tested the hypothesis that higher levels of bilirubin, a bile pigment with antioxidant properties, are associated with a decreased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the association between serum total bilirubin (TB) on CVD and CVD death. Serum TB was measured in a total of 8,844 subjects (4,196 males and 4,648 females) and evaluated for the development of new onset CVD from 2001 to 2012 (mean 8.1 years of follow-up). During the follow-up period, 689 cases of incident CVD (7.8%) were identified, and the prevalence of metabolic syndrome (MetS) at baseline was 26.1%. The prevalence of MetS decreased across bilirubin tertile categories. In addition to MetS itself, individual components of MetS significantly decreased with increased bilirubin tertiles. Moreover, the incidence of CVD decreased across bilirubin tertile categories. The hazard ratios (HRs) for developing coronary heart disease (CHD, HR 0.769, 95% CI 0.655–1.000) and CVD death (HR 0.513, 95% CI 0.267–0.985) was significantly lower in the highest tertile group (> 0.63 mg/dL) in comparison to the lowest tertile group (< 0.44 mg/dL) after adjusting for all confounding variables. In the present longitudinal study, a significant negative relationship was demonstrated between baseline bilirubin levels and incident CHD and CVD death. |
format | Online Article Text |
id | pubmed-5814053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58140532018-03-02 Relationship between serum bilirubin levels and cardiovascular disease Suh, Sunghwan Cho, Young Rak Park, Mi Kyoung Kim, Duk Kyu Cho, Nam H. Lee, Moon-Kyu PLoS One Research Article We tested the hypothesis that higher levels of bilirubin, a bile pigment with antioxidant properties, are associated with a decreased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the association between serum total bilirubin (TB) on CVD and CVD death. Serum TB was measured in a total of 8,844 subjects (4,196 males and 4,648 females) and evaluated for the development of new onset CVD from 2001 to 2012 (mean 8.1 years of follow-up). During the follow-up period, 689 cases of incident CVD (7.8%) were identified, and the prevalence of metabolic syndrome (MetS) at baseline was 26.1%. The prevalence of MetS decreased across bilirubin tertile categories. In addition to MetS itself, individual components of MetS significantly decreased with increased bilirubin tertiles. Moreover, the incidence of CVD decreased across bilirubin tertile categories. The hazard ratios (HRs) for developing coronary heart disease (CHD, HR 0.769, 95% CI 0.655–1.000) and CVD death (HR 0.513, 95% CI 0.267–0.985) was significantly lower in the highest tertile group (> 0.63 mg/dL) in comparison to the lowest tertile group (< 0.44 mg/dL) after adjusting for all confounding variables. In the present longitudinal study, a significant negative relationship was demonstrated between baseline bilirubin levels and incident CHD and CVD death. Public Library of Science 2018-02-15 /pmc/articles/PMC5814053/ /pubmed/29447261 http://dx.doi.org/10.1371/journal.pone.0193041 Text en © 2018 Suh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Suh, Sunghwan Cho, Young Rak Park, Mi Kyoung Kim, Duk Kyu Cho, Nam H. Lee, Moon-Kyu Relationship between serum bilirubin levels and cardiovascular disease |
title | Relationship between serum bilirubin levels and cardiovascular disease |
title_full | Relationship between serum bilirubin levels and cardiovascular disease |
title_fullStr | Relationship between serum bilirubin levels and cardiovascular disease |
title_full_unstemmed | Relationship between serum bilirubin levels and cardiovascular disease |
title_short | Relationship between serum bilirubin levels and cardiovascular disease |
title_sort | relationship between serum bilirubin levels and cardiovascular disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814053/ https://www.ncbi.nlm.nih.gov/pubmed/29447261 http://dx.doi.org/10.1371/journal.pone.0193041 |
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