Consecutive epigenetically-active agent combinations act in ID1-RUNX3-TET2 and HOXA pathways for Flt3ITD+ve AML

Co-occurrence of Flt3ITD and TET2 mutations provoke an animal model of AML by epigenetic repression of Wnt pathway antagonists, including RUNX3, and by hyperexpression of ID1, encoding Wnt agonist. These affect HOXA over-expression and treatment resistance. A comparable epigenetic phenotype was iden...

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Detalles Bibliográficos
Autores principales: Sayar, Hamid, Liu, Yan, Gao, Rui, Zaid, Mohammad Abu, Cripe, Larry D., Weisenbach, Jill, Sargent, Katie J., Nassiri, Mehdi, Li, Lang, Konig, Heiko, Suvannasankha, Attaya, Pan, Feng, Shanmugam, Rajasubramaniam, Goswami, Chirayu, Kapur, Reuben, Xu, Mingjiang, Boswell, H. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814168/
https://www.ncbi.nlm.nih.gov/pubmed/29464028
http://dx.doi.org/10.18632/oncotarget.23655

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