Rapid development of myeloproliferative neoplasm in mice with Ptpn11(D61Y) mutation and haploinsufficient for Dnmt3a

PTPN11 gain-of-function mutation is the most common mutation found in patients with juvenile myelomonocytic leukemia and DNMT3A loss occurs in over 20% of acute myeloid leukemia patients. We studied the combined effect of both Ptpn11 gain-of-function mutation (D61Y) and Dnmt3a haploinsufficiency on...

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Detalles Bibliográficos
Autores principales: Deng, Lisa, Richine, Briana M., Virts, Elizabeth L., Jideonwo-Auman, Victoria N., Chan, Rebecca J., Kapur, Reuben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814194/
https://www.ncbi.nlm.nih.gov/pubmed/29464054
http://dx.doi.org/10.18632/oncotarget.23680

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