Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma

Succinate dehydrogenase (SDH)-loss pheochromocytoma and paraganglioma (PPGL) are tumors driven by metabolic derangement. SDH loss leads to accumulation of intracellular succinate, which competitively inhibits dioxygenase enzymes, causing activation of pseudohypoxic signaling and hypermethylation of...

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Detalles Bibliográficos
Autores principales: Smestad, John, Hamidi, Oksana, Wang, Lin, Holte, Molly Nelson, Khazal, Fatimah Al, Erber, Luke, Chen, Yue, Maher, L. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814199/
https://www.ncbi.nlm.nih.gov/pubmed/29464059
http://dx.doi.org/10.18632/oncotarget.23639

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