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Prognostic significance of heparanase expression in primary and metastatic breast carcinoma
High levels of heparanase are detected in many types of tumors, associated with bad prognosis. Typically, heparanase levels are evaluated in a biopsy taken from the primary lesion, whereas its expression by the resulting metastases is most often unresolved. This becomes critically important as anti-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814208/ https://www.ncbi.nlm.nih.gov/pubmed/29464068 http://dx.doi.org/10.18632/oncotarget.23560 |
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author | Vornicova, Olga Naroditsky, Inna Boyango, Ilanit Shachar, Shlomit S. Mashiach, Tanya Ilan, Neta Vlodavsky, Israel Bar-Sela, Gil |
author_facet | Vornicova, Olga Naroditsky, Inna Boyango, Ilanit Shachar, Shlomit S. Mashiach, Tanya Ilan, Neta Vlodavsky, Israel Bar-Sela, Gil |
author_sort | Vornicova, Olga |
collection | PubMed |
description | High levels of heparanase are detected in many types of tumors, associated with bad prognosis. Typically, heparanase levels are evaluated in a biopsy taken from the primary lesion, whereas its expression by the resulting metastases is most often unresolved. This becomes critically important as anti-heparanase compounds enter advanced clinical trials. Here, we examined the expression of heparanase in pairs of primary and the resulting distant metastases of breast carcinoma. Interestingly, we found that heparanase expression in the metastatic lesion does not always reflect its expression in the primary tumor. Accordingly, in some cases, the primary lesion was stained positive for heparanase while the metastasis stained negative, and vice versa. Heparanase discordance occurred in 38% of the patients, higher than that reported for hormone receptors, and was associated with bad prognosis. Thus, examination of heparanase levels in the tumor metastases should be evaluated for most efficient precision medicine applying heparanase inhibitors. Furthermore, we found that in stage I breast cancer patients strong heparanase staining is associated with shorter overall survival. Thus, heparanase levels can assist in the diagnosis and in determining the necessity and type of treatment in early stage breast cancer. |
format | Online Article Text |
id | pubmed-5814208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-58142082018-02-20 Prognostic significance of heparanase expression in primary and metastatic breast carcinoma Vornicova, Olga Naroditsky, Inna Boyango, Ilanit Shachar, Shlomit S. Mashiach, Tanya Ilan, Neta Vlodavsky, Israel Bar-Sela, Gil Oncotarget Research Paper High levels of heparanase are detected in many types of tumors, associated with bad prognosis. Typically, heparanase levels are evaluated in a biopsy taken from the primary lesion, whereas its expression by the resulting metastases is most often unresolved. This becomes critically important as anti-heparanase compounds enter advanced clinical trials. Here, we examined the expression of heparanase in pairs of primary and the resulting distant metastases of breast carcinoma. Interestingly, we found that heparanase expression in the metastatic lesion does not always reflect its expression in the primary tumor. Accordingly, in some cases, the primary lesion was stained positive for heparanase while the metastasis stained negative, and vice versa. Heparanase discordance occurred in 38% of the patients, higher than that reported for hormone receptors, and was associated with bad prognosis. Thus, examination of heparanase levels in the tumor metastases should be evaluated for most efficient precision medicine applying heparanase inhibitors. Furthermore, we found that in stage I breast cancer patients strong heparanase staining is associated with shorter overall survival. Thus, heparanase levels can assist in the diagnosis and in determining the necessity and type of treatment in early stage breast cancer. Impact Journals LLC 2017-12-21 /pmc/articles/PMC5814208/ /pubmed/29464068 http://dx.doi.org/10.18632/oncotarget.23560 Text en Copyright: © 2018 Vornicova et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Vornicova, Olga Naroditsky, Inna Boyango, Ilanit Shachar, Shlomit S. Mashiach, Tanya Ilan, Neta Vlodavsky, Israel Bar-Sela, Gil Prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
title | Prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
title_full | Prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
title_fullStr | Prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
title_full_unstemmed | Prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
title_short | Prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
title_sort | prognostic significance of heparanase expression in primary and metastatic breast carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814208/ https://www.ncbi.nlm.nih.gov/pubmed/29464068 http://dx.doi.org/10.18632/oncotarget.23560 |
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