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2-Amino-3-methylcarboxy-5-heptyl-thiophene (TJ191) is a selective anti-cancer small molecule that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells
Current chemotherapy regimens often include non-specific cytostatic/cytotoxic drugs, which do not distinguish between normal and tumor cells, therefore causing considerable systemic toxicity. We previously reported the synthesis and anti-proliferative activity of a novel synthetic 2-aminothiophene-3...
Autores principales: | El-Gazzar, Ahmed, Noppen, Sam, Thomas, Joice, Dehaen, Wim, Balzarini, Jan, Liekens, Sandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814210/ https://www.ncbi.nlm.nih.gov/pubmed/29464070 http://dx.doi.org/10.18632/oncotarget.23501 |
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