Cargando…
T cell infiltration into Ewing sarcomas is associated with local expression of immune-inhibitory HLA-G
Ewing sarcoma (EwS) is an aggressive mesenchymal cancer of bones or soft tissues. The mechanisms by which this cancer interacts with the host immune system to induce tolerance are not well understood. We hypothesized that the non-classical, immune-inhibitory HLA-molecule HLA-G contributes to immune...
Autores principales: | Spurny, Christian, Kailayangiri, Sareetha, Altvater, Bianca, Jamitzky, Silke, Hartmann, Wolfgang, Wardelmann, Eva, Ranft, Andreas, Dirksen, Uta, Amler, Susanne, Hardes, Jendrik, Fluegge, Maike, Meltzer, Jutta, Farwick, Nicole, Greune, Lea, Rossig, Claudia |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814230/ https://www.ncbi.nlm.nih.gov/pubmed/29464090 http://dx.doi.org/10.18632/oncotarget.23815 |
Ejemplares similares
-
HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells
por: Altvater, Bianca, et al.
Publicado: (2021) -
Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers
por: Rossig, Claudia, et al.
Publicado: (2018) -
Overcoming Heterogeneity of Antigen Expression for Effective CAR T Cell Targeting of Cancers
por: Kailayangiri, Sareetha, et al.
Publicado: (2020) -
Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma
por: Fuest, Sebastian, et al.
Publicado: (2022) -
Surface expression of the immunotherapeutic target G(D2)
in osteosarcoma depends on cell confluency
por: Wiebel, Malena, et al.
Publicado: (2021)