A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine

Decitabine is widely accepted as the treatment options for elderly acute myeloid leukemia (AML) patients. However, the efficacy has yet been assessed in Asian population. We retrospectively analyzed the outcomes of 80 Korean elderly AML patients who were treated with decitabine. The median age was 7...

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Autores principales: Yi, Jun Ho, Park, Silvia, Kim, Jung Han, Won, Young-Woong, Lim, Do Hyoung, Han, Boram, Uhm, Jieun, Kim, Hae Su, Jung, Chul Won, Jang, Jun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Clinical Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814236/
https://www.ncbi.nlm.nih.gov/pubmed/29464096
http://dx.doi.org/10.18632/oncotarget.23823
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author Yi, Jun Ho
Park, Silvia
Kim, Jung Han
Won, Young-Woong
Lim, Do Hyoung
Han, Boram
Uhm, Jieun
Kim, Hae Su
Jung, Chul Won
Jang, Jun Ho
author_facet Yi, Jun Ho
Park, Silvia
Kim, Jung Han
Won, Young-Woong
Lim, Do Hyoung
Han, Boram
Uhm, Jieun
Kim, Hae Su
Jung, Chul Won
Jang, Jun Ho
author_sort Yi, Jun Ho
collection PubMed
description Decitabine is widely accepted as the treatment options for elderly acute myeloid leukemia (AML) patients. However, the efficacy has yet been assessed in Asian population. We retrospectively analyzed the outcomes of 80 Korean elderly AML patients who were treated with decitabine. The median age was 74 years (range, 64 to 86 years) and 6 (7.5%), 48 (60.0%), and 25 (31.3%) patients were categorized to favorable, intermediate, and poor risk group, respectively. The median OS was 10.2 months (95% CI 5.0–15.4). Given that decitabine treatment demonstrated improved clinical outcomes, it could be considered as one of the first-line treatment for Korean elderly AML patients.
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spelling pubmed-58142362018-02-20 A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine Yi, Jun Ho Park, Silvia Kim, Jung Han Won, Young-Woong Lim, Do Hyoung Han, Boram Uhm, Jieun Kim, Hae Su Jung, Chul Won Jang, Jun Ho Oncotarget Clinical Research Paper Decitabine is widely accepted as the treatment options for elderly acute myeloid leukemia (AML) patients. However, the efficacy has yet been assessed in Asian population. We retrospectively analyzed the outcomes of 80 Korean elderly AML patients who were treated with decitabine. The median age was 74 years (range, 64 to 86 years) and 6 (7.5%), 48 (60.0%), and 25 (31.3%) patients were categorized to favorable, intermediate, and poor risk group, respectively. The median OS was 10.2 months (95% CI 5.0–15.4). Given that decitabine treatment demonstrated improved clinical outcomes, it could be considered as one of the first-line treatment for Korean elderly AML patients. Impact Journals LLC 2018-01-02 /pmc/articles/PMC5814236/ /pubmed/29464096 http://dx.doi.org/10.18632/oncotarget.23823 Text en Copyright: © 2018 Yi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Yi, Jun Ho
Park, Silvia
Kim, Jung Han
Won, Young-Woong
Lim, Do Hyoung
Han, Boram
Uhm, Jieun
Kim, Hae Su
Jung, Chul Won
Jang, Jun Ho
A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
title A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
title_full A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
title_fullStr A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
title_full_unstemmed A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
title_short A multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
title_sort multicenter, retrospective analysis of elderly patients with acute myeloid leukemia who were treated with decitabine
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814236/
https://www.ncbi.nlm.nih.gov/pubmed/29464096
http://dx.doi.org/10.18632/oncotarget.23823
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