Mutations in DNA repair genes are associated with increased neo-antigen load and activated T cell infiltration in lung adenocarcinoma

Mutations in DNA repair genes lead to increased genomic instability and mutation frequency. These mutations represent potential biomarkers for cancer immunotherapy efficacy, as high tumor mutational burden has been associated with increased neo-antigens and tumor infiltrating lymphocytes. While mism...

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Detalles Bibliográficos
Autores principales: Chae, Young Kwang, Anker, Jonathan F., Bais, Preeti, Namburi, Sandeep, Giles, Francis J., Chuang, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814272/
https://www.ncbi.nlm.nih.gov/pubmed/29487705
http://dx.doi.org/10.18632/oncotarget.23742

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