Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome–like acute B-cell lymphoblastic leukemia

Patients with cytokine receptor-like factor 2 rearranged (CRLF2-re) subgroup Philadelphia chromosome–like B-cell acute lymphoblastic leukemia (Ph-like B-ALL) have a high relapse rate and poor clinical outcomes. CRFL2-re Ph-like B-ALL is characterized by heightened activation of multiple signaling pa...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Shi, Ce, Han, Lina, Jain, Nitin, Roberts, Kathryn G., Ma, Helen, Cai, Tianyu, Cavazos, Antonio, Tabe, Yoko, Jacamo, Rodrigo O., Mu, Hong, Zhao, Yang, Wang, Jing, Wu, Shuo-Chieh, Cao, Fenglin, Zeng, Zhihong, Zhou, Jin, Mi, Yingchang, Jabbour, Elias J., Levine, Ross, Tasian, Sarah K., Mullighan, Charles G., Weinstock, David M., Fruman, David A., Konopleva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814279/
https://www.ncbi.nlm.nih.gov/pubmed/29487712
http://dx.doi.org/10.18632/oncotarget.24261

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