Structural basis for DNMT3A-mediated de novo DNA methylation

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) is essential for genome regulation and development(1, 2). Dysregulation of this process is implicated in various diseases, notably cancer. However, the mechanisms underlying DNMT3 substrate recognition and enzymatic specif...

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Detalles Bibliográficos
Autores principales: Zhang, Zhi-Min, Lu, Rui, Wang, Pengcheng, Yu, Yang, Chen, Dong-Liang, Gao, Linfeng, Liu, Shuo, Ji, Debin, Rothbart, Scott B, Wang, Yinsheng, Wang, Gang Greg, Song, Jikui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814352/
https://www.ncbi.nlm.nih.gov/pubmed/29414941
http://dx.doi.org/10.1038/nature25477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814352/
https://www.ncbi.nlm.nih.gov/pubmed/29414941
http://dx.doi.org/10.1038/nature25477

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