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Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Who...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814423/ https://www.ncbi.nlm.nih.gov/pubmed/29449638 http://dx.doi.org/10.1038/s41598-018-21551-2 |
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author | Heiss, Kirsten Maier, Marion Irmgard Hoffmann, Angelika Frank, Roland Bendszus, Martin Mueller, Ann-Kristin Pfeil, Johannes |
author_facet | Heiss, Kirsten Maier, Marion Irmgard Hoffmann, Angelika Frank, Roland Bendszus, Martin Mueller, Ann-Kristin Pfeil, Johannes |
author_sort | Heiss, Kirsten |
collection | PubMed |
description | Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria. |
format | Online Article Text |
id | pubmed-5814423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58144232018-02-21 Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization Heiss, Kirsten Maier, Marion Irmgard Hoffmann, Angelika Frank, Roland Bendszus, Martin Mueller, Ann-Kristin Pfeil, Johannes Sci Rep Article Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria. Nature Publishing Group UK 2018-02-15 /pmc/articles/PMC5814423/ /pubmed/29449638 http://dx.doi.org/10.1038/s41598-018-21551-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Heiss, Kirsten Maier, Marion Irmgard Hoffmann, Angelika Frank, Roland Bendszus, Martin Mueller, Ann-Kristin Pfeil, Johannes Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
title | Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
title_full | Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
title_fullStr | Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
title_full_unstemmed | Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
title_short | Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
title_sort | protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814423/ https://www.ncbi.nlm.nih.gov/pubmed/29449638 http://dx.doi.org/10.1038/s41598-018-21551-2 |
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