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Chronic ET(A) antagonist reverses hypertension and impairment of structure and function of peripheral small arteries in aortic stiffening
Arterial stiffness may contribute to the pathogenesis of hypertension. The goal of this study is to elucidate the role of Endothelin-1 (ET-1) in aortic stiffening-induced hypertension through ET(A) receptor activation. An increase in aortic stiffness was created by use of a non-constrictive restrain...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814460/ https://www.ncbi.nlm.nih.gov/pubmed/29449619 http://dx.doi.org/10.1038/s41598-018-20439-5 |