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Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury

This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8–14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI a...

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Autores principales: Königs, Marsh, Pouwels, Petra JW, Ernest van Heurn, LW, Bakx, Roel, Jeroen Vermeulen, R, Carel Goslings, J, Poll-The, Bwee Tien, van der Wees, Marleen, Catsman-Berrevoets, Coriene E, Oosterlaan, Jaap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814510/
https://www.ncbi.nlm.nih.gov/pubmed/28092022
http://dx.doi.org/10.1007/s11682-017-9673-3
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author Königs, Marsh
Pouwels, Petra JW
Ernest van Heurn, LW
Bakx, Roel
Jeroen Vermeulen, R
Carel Goslings, J
Poll-The, Bwee Tien
van der Wees, Marleen
Catsman-Berrevoets, Coriene E
Oosterlaan, Jaap
author_facet Königs, Marsh
Pouwels, Petra JW
Ernest van Heurn, LW
Bakx, Roel
Jeroen Vermeulen, R
Carel Goslings, J
Poll-The, Bwee Tien
van der Wees, Marleen
Catsman-Berrevoets, Coriene E
Oosterlaan, Jaap
author_sort Königs, Marsh
collection PubMed
description This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8–14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mild(RF+), n = 20) or moderate/severe TBI (n = 17) at 2.8 years post-injury. Neuroimaging measures included: acute computed tomography (CT), volumetric analysis on post-acute conventional T1-weighted magnetic resonance imaging (MRI) and post-acute diffusion tensor imaging (DTI, analyzed using tract-based spatial statistics and voxel-wise regression). Functional outcome was measured using Common Data Elements for neurocognitive and behavioral functioning. The results show that intracranial pathology on acute CT-scans was more prevalent after moderate/severe TBI (65%) than after mild(RF+) TBI (35%; p = .035), while both groups had decreased white matter volume on conventional MRI (ps ≤ .029, ds ≥ −0.74). The moderate/severe TBI group further showed decreased fractional anisotropy (FA) in a widespread cluster affecting all white matter tracts, in which regional associations with neurocognitive functioning were observed (FSIQ, Digit Span and RAVLT Encoding) that consistently involved the corpus callosum. FA had superior predictive value for functional outcome (i.e. intelligence, attention and working memory, encoding in verbal memory and internalizing problems) relative to acute CT-scanning (i.e. internalizing problems) and conventional MRI (no predictive value). We conclude that children with mild(RF+) TBI and moderate/severe TBI are at risk of persistent white matter abnormality. Furthermore, DTI has superior predictive value for neurocognitive out-come relative to conventional neuroimaging. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11682-017-9673-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-58145102018-02-26 Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury Königs, Marsh Pouwels, Petra JW Ernest van Heurn, LW Bakx, Roel Jeroen Vermeulen, R Carel Goslings, J Poll-The, Bwee Tien van der Wees, Marleen Catsman-Berrevoets, Coriene E Oosterlaan, Jaap Brain Imaging Behav Original Research This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8–14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mild(RF+), n = 20) or moderate/severe TBI (n = 17) at 2.8 years post-injury. Neuroimaging measures included: acute computed tomography (CT), volumetric analysis on post-acute conventional T1-weighted magnetic resonance imaging (MRI) and post-acute diffusion tensor imaging (DTI, analyzed using tract-based spatial statistics and voxel-wise regression). Functional outcome was measured using Common Data Elements for neurocognitive and behavioral functioning. The results show that intracranial pathology on acute CT-scans was more prevalent after moderate/severe TBI (65%) than after mild(RF+) TBI (35%; p = .035), while both groups had decreased white matter volume on conventional MRI (ps ≤ .029, ds ≥ −0.74). The moderate/severe TBI group further showed decreased fractional anisotropy (FA) in a widespread cluster affecting all white matter tracts, in which regional associations with neurocognitive functioning were observed (FSIQ, Digit Span and RAVLT Encoding) that consistently involved the corpus callosum. FA had superior predictive value for functional outcome (i.e. intelligence, attention and working memory, encoding in verbal memory and internalizing problems) relative to acute CT-scanning (i.e. internalizing problems) and conventional MRI (no predictive value). We conclude that children with mild(RF+) TBI and moderate/severe TBI are at risk of persistent white matter abnormality. Furthermore, DTI has superior predictive value for neurocognitive out-come relative to conventional neuroimaging. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11682-017-9673-3) contains supplementary material, which is available to authorized users. Springer US 2017-01-14 2018 /pmc/articles/PMC5814510/ /pubmed/28092022 http://dx.doi.org/10.1007/s11682-017-9673-3 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Königs, Marsh
Pouwels, Petra JW
Ernest van Heurn, LW
Bakx, Roel
Jeroen Vermeulen, R
Carel Goslings, J
Poll-The, Bwee Tien
van der Wees, Marleen
Catsman-Berrevoets, Coriene E
Oosterlaan, Jaap
Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
title Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
title_full Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
title_fullStr Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
title_full_unstemmed Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
title_short Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
title_sort relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814510/
https://www.ncbi.nlm.nih.gov/pubmed/28092022
http://dx.doi.org/10.1007/s11682-017-9673-3
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