6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2

Ubiquitin-specific protease 2 (USP2) belongs to the family of deubiquitinases that can rescue protein targets from proteasomal degradation by reversing their ubiquitination. In various cancers, including prostate cancer and ovarian carcinoma, upregulation of USP2 leads to an increase in the levels o...

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Detalles Bibliográficos
Autores principales: Chuang, Shang-Ju, Cheng, Shu-Chun, Tang, Hui-Chi, Sun, Chiao-Yin, Chou, Chi-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814560/
https://www.ncbi.nlm.nih.gov/pubmed/29449607
http://dx.doi.org/10.1038/s41598-018-21476-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814560/
https://www.ncbi.nlm.nih.gov/pubmed/29449607
http://dx.doi.org/10.1038/s41598-018-21476-w

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