Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry

Therapeutic plasma exchange (TPE) is a potentially life-saving procedure which effectively removes donor-specific human leukocyte antigen (HLA) antibodies from the bloodstream, allowing critically ill heart transplant recipients to receive a donor organ with less wait time, and reducing the risk of...

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Autores principales: Crabbe, Andrew, McNeil, John S., Deshpande, Seema P., Kon, Zachary, Pham, Si M., Tanaka, Kenichi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814793/
https://www.ncbi.nlm.nih.gov/pubmed/29492426
http://dx.doi.org/10.1186/s40981-016-0058-1
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author Crabbe, Andrew
McNeil, John S.
Deshpande, Seema P.
Kon, Zachary
Pham, Si M.
Tanaka, Kenichi A.
author_facet Crabbe, Andrew
McNeil, John S.
Deshpande, Seema P.
Kon, Zachary
Pham, Si M.
Tanaka, Kenichi A.
author_sort Crabbe, Andrew
collection PubMed
description Therapeutic plasma exchange (TPE) is a potentially life-saving procedure which effectively removes donor-specific human leukocyte antigen (HLA) antibodies from the bloodstream, allowing critically ill heart transplant recipients to receive a donor organ with less wait time, and reducing the risk of acute organ rejection. The bulk of coagulation factors is initially removed from the blood during TPE using albumin and is later replaced with allogeneic plasma. Coagulopathy may develop during TPE and then can persist due to intraoperative blood loss and hemodilution during surgery and cardiopulmonary bypass. We hereby describe the utility of rotational thromboelastometry to assess rapid coagulation changes during TPE and subsequent heart transplant (HT) surgery.
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spelling pubmed-58147932018-02-26 Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry Crabbe, Andrew McNeil, John S. Deshpande, Seema P. Kon, Zachary Pham, Si M. Tanaka, Kenichi A. JA Clin Rep Case Report Therapeutic plasma exchange (TPE) is a potentially life-saving procedure which effectively removes donor-specific human leukocyte antigen (HLA) antibodies from the bloodstream, allowing critically ill heart transplant recipients to receive a donor organ with less wait time, and reducing the risk of acute organ rejection. The bulk of coagulation factors is initially removed from the blood during TPE using albumin and is later replaced with allogeneic plasma. Coagulopathy may develop during TPE and then can persist due to intraoperative blood loss and hemodilution during surgery and cardiopulmonary bypass. We hereby describe the utility of rotational thromboelastometry to assess rapid coagulation changes during TPE and subsequent heart transplant (HT) surgery. Springer Berlin Heidelberg 2016-10-19 2016 /pmc/articles/PMC5814793/ /pubmed/29492426 http://dx.doi.org/10.1186/s40981-016-0058-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Crabbe, Andrew
McNeil, John S.
Deshpande, Seema P.
Kon, Zachary
Pham, Si M.
Tanaka, Kenichi A.
Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
title Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
title_full Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
title_fullStr Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
title_full_unstemmed Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
title_short Therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
title_sort therapeutic plasma exchange in heart transplantation: role of coagulation assessment with thromboelastometry
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814793/
https://www.ncbi.nlm.nih.gov/pubmed/29492426
http://dx.doi.org/10.1186/s40981-016-0058-1
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