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Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni
DNA recombination is required for effective segregation and diversification of genomes and for the successful completion of meiosis. Recent studies in various species hybrids have demonstrated a genetic link between DNA recombination and speciation. Consistent with this, we observed a striking suppr...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814819/ https://www.ncbi.nlm.nih.gov/pubmed/29325078 http://dx.doi.org/10.1093/nar/gkx1277 |
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author | Ren, Xiaoliang Li, Runsheng Wei, Xiaolin Bi, Yu Ho, Vincy Wing Sze Ding, Qiutao Xu, Zhichao Zhang, Zhihong Hsieh, Chia-Ling Young, Amanda Zeng, Jianyang Liu, Xiao Zhao, Zhongying |
author_facet | Ren, Xiaoliang Li, Runsheng Wei, Xiaolin Bi, Yu Ho, Vincy Wing Sze Ding, Qiutao Xu, Zhichao Zhang, Zhihong Hsieh, Chia-Ling Young, Amanda Zeng, Jianyang Liu, Xiao Zhao, Zhongying |
author_sort | Ren, Xiaoliang |
collection | PubMed |
description | DNA recombination is required for effective segregation and diversification of genomes and for the successful completion of meiosis. Recent studies in various species hybrids have demonstrated a genetic link between DNA recombination and speciation. Consistent with this, we observed a striking suppression of recombination in the hybrids between two nematodes, the hermaphroditic Caenorhabditis briggsae and the gonochoristic C. nigoni. To unravel the molecular basis underlying the recombination suppression in their hybrids, we generated a C. nigoni genome with chromosome-level contiguity and produced an improved C. briggsae genome with resolved gaps up to 2.8 Mb. The genome alignment reveals not only high sequence divergences but also pervasive intra- and inter-chromosomal sequence re-arrangements between the two species, which are plausible culprits for the observed suppression. Comparison of recombination boundary sequences suggests that recombination in the hybrid requires extensive sequence homology, which is rarely seen between the two genomes. The new genomes and genomic libraries form invaluable resources for studying genome evolution, hybrid incompatibilities and sex evolution for this pair of model species. |
format | Online Article Text |
id | pubmed-5814819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58148192018-02-23 Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni Ren, Xiaoliang Li, Runsheng Wei, Xiaolin Bi, Yu Ho, Vincy Wing Sze Ding, Qiutao Xu, Zhichao Zhang, Zhihong Hsieh, Chia-Ling Young, Amanda Zeng, Jianyang Liu, Xiao Zhao, Zhongying Nucleic Acids Res Genomics DNA recombination is required for effective segregation and diversification of genomes and for the successful completion of meiosis. Recent studies in various species hybrids have demonstrated a genetic link between DNA recombination and speciation. Consistent with this, we observed a striking suppression of recombination in the hybrids between two nematodes, the hermaphroditic Caenorhabditis briggsae and the gonochoristic C. nigoni. To unravel the molecular basis underlying the recombination suppression in their hybrids, we generated a C. nigoni genome with chromosome-level contiguity and produced an improved C. briggsae genome with resolved gaps up to 2.8 Mb. The genome alignment reveals not only high sequence divergences but also pervasive intra- and inter-chromosomal sequence re-arrangements between the two species, which are plausible culprits for the observed suppression. Comparison of recombination boundary sequences suggests that recombination in the hybrid requires extensive sequence homology, which is rarely seen between the two genomes. The new genomes and genomic libraries form invaluable resources for studying genome evolution, hybrid incompatibilities and sex evolution for this pair of model species. Oxford University Press 2018-02-16 2018-01-09 /pmc/articles/PMC5814819/ /pubmed/29325078 http://dx.doi.org/10.1093/nar/gkx1277 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Genomics Ren, Xiaoliang Li, Runsheng Wei, Xiaolin Bi, Yu Ho, Vincy Wing Sze Ding, Qiutao Xu, Zhichao Zhang, Zhihong Hsieh, Chia-Ling Young, Amanda Zeng, Jianyang Liu, Xiao Zhao, Zhongying Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni |
title | Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni |
title_full | Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni |
title_fullStr | Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni |
title_full_unstemmed | Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni |
title_short | Genomic basis of recombination suppression in the hybrid between Caenorhabditis briggsae and C. nigoni |
title_sort | genomic basis of recombination suppression in the hybrid between caenorhabditis briggsae and c. nigoni |
topic | Genomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814819/ https://www.ncbi.nlm.nih.gov/pubmed/29325078 http://dx.doi.org/10.1093/nar/gkx1277 |
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