Oxygen gradients can determine epigenetic asymmetry and cellular differentiation via differential regulation of Tet activity in embryonic stem cells

Graded levels of molecular oxygen (O(2)) exist within developing mammalian embryos and can differentially regulate cellular specification pathways. During differentiation, cells acquire distinct epigenetic landscapes, which determine their function, however the mechanisms which regulate this are poo...

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Detalles Bibliográficos
Autores principales: Burr, Simon, Caldwell, Anna, Chong, Mei, Beretta, Matteo, Metcalf, Stephen, Hancock, Matthew, Arno, Matthew, Balu, Sucharitha, Kropf, Valeria Leon, Mistry, Rajesh K, Shah, Ajay M, Mann, Giovanni E, Brewer, Alison C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814828/
https://www.ncbi.nlm.nih.gov/pubmed/29186571
http://dx.doi.org/10.1093/nar/gkx1197

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