Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase

The elongation of single-stranded DNA repeats at the 3′-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes. Abnormal activation of telomerase leads to uncontrolled cell division, whereas its down-regulation is attributed to ageing and several pathologies...

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Detalles Bibliográficos
Autores principales: Petrova, Olga A, Mantsyzov, Alexey B, Rodina, Elena V, Efimov, Sergey V, Hackenberg, Claudia, Hakanpää, Johanna, Klochkov, Vladimir V, Lebedev, Andrej A, Chugunova, Anastasia A, Malyavko, Alexander N, Zatsepin, Timofei S, Mishin, Alexey V, Zvereva, Maria I, Lamzin, Victor S, Dontsova, Olga A, Polshakov, Vladimir I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814841/
https://www.ncbi.nlm.nih.gov/pubmed/29294091
http://dx.doi.org/10.1093/nar/gkx1275

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